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Publications

  • M Ou, F Kuo, ML Olsen, G Du, DK Mulkey, Isoflurane inhibits CO2/H+-sensitive Kir4.1-Kir5.1 channels in brainstem astrocytes, J Neurophysiol. 2020 Jul 29. PMID: 32727273
  • KC Patterson, U Kahanovitch, CM Gonçalves, JJ Hablitz, A Staruschenko, DK Mulkey, ML Olsen. Kir5.1-dependent CO2-Sensitive Currents Contribute to Astrocyte Heterogeneity across Brain Regions, in press, Glia, July 2020
  • JL Boni, SE Nwaobi, CL. Floyd and ML Olsen.  DNA methylation: a mechanism for sustained alteration of Kir4.1 expression following central nervous system insult. Glia. 2020 Jul;68(7):1495-1512. PMID: 32068308
  • Uri Kahnovitch, ML Olsen, invited “Spotlight”, Glial SIK3: a central player in ion and volume homeostasis in Drosophila peripheral nerves, Journal of Cell Biology,  2019, PMID 31723008 
  • LM Holt, NA Pacheco, RD Hernandez,  NL Pacheco, BT Ceja, M Hussain and ML Olsen.  Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1, eLIFE,  2019, PMID 31433295
  • U Kahanovitch,  KC Patterson, R Hernandez and ML Olsen. Glial dysfunction in MeCP2 deficiency models:    Implications for Rett syndrome, invited review,  International Journal of  Molecular Sciences, 2019 Aug 5;20(15), PMID 31387202
  • Holt LM, Stoyanof T and ML Olsen. Magnetic cell sorting for in vivo and in vitro astrocyte, neuron, and microglia analysis, Current  Protocols in Neuroscience, invited, 2019, Jun;88(1):e71, PMID 31216394
  • M Brenner, A Messing and ML Olsen. AP-1 and the injury response of the GFAP promoter, Journal of Neuroscience Research, 2019 Feb;97(2):149-161. PMID 30345544
  • S James, V Hawkins, B Barna, D Ruskin, S Masino, T Moreira, ML Olsen, DK Mulkey. Adenosine signaling though A1 receptors inhibits chemosensitive neurons in the retrotrapezoid nucleus. eNEURO  2018 Dec 14;5(6). PMID 30627640
  • U Kahanakovitch, VA Cuddapah, NL Pacheco, LM Holt, AK Percy, DK Mulkey and ML Olsen. MeCP2 deficiency leads to loss of glial Kir4.1, eNEURO, 2018, PMID 29464197
  • NL Pacheco, LM Holt, DA Crossman and ML Olsen.  RNA sequencing and novel proteomics approaches reveal multi-cellular deficits in cortex of Rett syndrome mice, Molecular Autism, 2017, 24; 8:56 PMID 29090078
  • L Stewart, K Wang, A Khan, S Pati, D Pizarro, S. Buckingham, ML Olsen, J Chatham, and L McMahon, Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus, Journal of Neuroscience, 2017, 23;37(34):8207 – 8215, PMID 28760863
  • Stoica, BR Larsen, M Assentoft, RH Jensen, LM Holt, F  Vilhardt, B Vilsen, K Lykke-Hartman, ML Olsen and N MacAulay, The a2β2 isoform combination dominates the astrocytic Na+/K+-ATPase activity and is rendered non-functional by the G301R familial hemiplegic migraine type 2-associated mutation, Glia, 2017, 65(11):1777-1793, PMID: 28787093
  • KC Patterson, KM Arps, VE Hawkins, DK Mulkey and ML Olsen, Behavioral and Motor Phenotypes in a Novel Rat Model of Rett Syndrome, Human Molecular Genetics, 2016, 1;25(15):3303-3320, PMID:27329765
  • SE Nwaobi, VA Cuddapah, KC Patterson, AC Randolph, and ML  Olsen. Physiology and function of the glial inwardly rectifying potassium channel Kir4.1, review,  Acta Neuropathologica (2016)  March PMID: 26961251
  • LM Holt and ML Olsen, Novel applications of magnetic cell sorting to analyze CNS cell-type specific gene and protein expression, PLos One (2016) Feb 26;11(2), PMID 26919701
  • ML Olsen*, B.S. Khakh, S.N. Skatchkov, M. Zhou, C.J., Rouach N. Emerging insight into the critical role of astrocyte ion channels in homeostasis and neuron-glia signaling. Journal of Neuroscience (2015) 14;35(41):13827-35, PMCID PMC4604221 *Corresponding Author
  • VA Cuddapah, SE Nwaobi, AK Percy, and ML Olsen. MECP2’s role in regulating neural activity: pathophysiological perspectives,  Degenerative Neurological and Neuromuscular Disease (2015) 5:103-116, PMID 32669918
  • HR Minkel, TZ Anwer, KM Arps, M Brenner, ML Olsen. Elevated GFAP induces astrocyte dysfunction in caudal brain regions:  a potential mechanism for hindbrain involved symptoms in type II Alexander Disease, Glia (2015) Dec;63(12)2285-97, PMID:26190408
  • SE Nwaobi and ML Olsen. Correlating gene-specific DNA methylation changes with expression and transcriptional activity of astrocytic KCNJ10 (Kir4.1), Journal of Visualized Experiments (2015) Sep 26: (103), PMID 26436772
  • SL Campbell, JJ Hablitz and ML Olsen. Insufficient GLT-1 Glutamate Transport and Altered Astrocyte Biophysical Properties Contributes to Hyperexcitability in Cortical Dysplasia, Frontiers in Molecular Neuroscience (2014) Dec 17;8:425. PMID:25565960
  • X Tong, Y  Ao, GC Faas, SE Nwaobi, J Xu, MD Haustein, MA Anderson, I Mody, ML Olsen, M.V. Sofroniew, B.S. Khakh.  Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nature Neuroscience (2014) Mar 30. PMID:24686787
  • VA Cuddapah, RB Pillai, KV Shekar, JB Lane, KJ Motil, SA Skinner, G McGwin, DC Tarquinio, DG Glaze, WE Kaufmann, A K Percy, JL Neul, ML Olsen.   Methyl-CpG-binding protein 2 (MEPC2) mutation type is associated with disease severity in Rett Syndrome, Journal of Medical Genetics (2014) Mar;51(3):152-8,  PMID 24399845 This article was featured as editor’s choice
  • SE Nwaobi, SR Peramsetty, E Lin and ML Olsen, DNA methylation is a critical regulator of Kir4.1 in CNS development, Glia (2014)  Mar;62(3):411-27, 2014 PMID:2441522
  • R Raphemot, R Kadakia, ML Olsen, S Banerjee, E Days, SS Smith, CD Weaver and JS Denton.  Development and validation of fluorescence- and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1. Assay and Drug Development Technologies, (2013) Assay Drug Dev Technol. 2013 Nov-Dec;11(9-10):532-43. PMID: 24266659
  • ML Olsen, SL Campbell, C.L. Floyd, H.  Sontheimer, Spinal Cord Injury in vivo Causes Wide-Spread, Persistent Loss of Kir4.1 and GLT-1: Potential Benefits of Treatment with 17β-Estradiol, Brain (2010)  PMID: 20375134
  • ML Olsen and H Sontheimer. Functional Implications for Kir4.1 Channels in Glial Biology: From K+ Buffering to Cell Differentiation, Journal of Neurochemistry (2008) 107, 589–601
  • AK Weaver, ML Olsen, MB McFerrin and H Sontheimer. BK Channels are Coupled to IP3-receptors via Lipid Rafts: a Novel Mechanism for Coupling [Ca2+]i to Channel Activation, Journal of Biological Chemistry (2007) 26;282(43):31558-68, PMID: 2227909
  • CM Habela, ML Olsen and H Sontheimer.  ClC3 Is a Critical Regulator of Cell Cycle in Normal and Malignant Cells, Journal of Neuroscience (2008) 28(37):9205-17, PMID: 18784301
  • ML Olsen, SL Campbell and H Sontheimer. Differential Distribution of Kir4.1 in Spinal Cord Astrocytes Suggests Regional Differences in K+ Homeostasis, Journal of Neurophysiology (2007)  98(2):786-93 , PMCID: 2040512
  • ML Olsen, H Higashimori, SL Campbell, JJ Hablitz and H Sontheimer. Functional Expression of Kir4.1 Channels in Spinal Cord Astrocytes, Glia (2006) 53(5):516-28, PMCID: 2553202, cover art
  • ML Olsen, AK Weaver, P Ritch, H Sontheimer. Modulation of  Glioma BK (gBK) Channels via erbB2, Journal of Neuroscience Research (2005) 15;81(2):179-89, PMID: 15948146
  • ML Olsen, H Sontheimer. Mislocalization of Kir Channels in Malignant Glia, Glia  (2004) 46:63-73, PMCID: 2548404, cover art
  • ML Olsen, S Schade, SA Lyons, MD Amaral, H Sontheimer. Expression of Voltage-Gated Chloride Channels in Human Glioma Cells, Journal of Neuroscience (2003) 23(13)5572-5582, PMID: 12843258

Invited Book Chapters

  • LM Holt and ML Olsen, Glial Cell Function in Memory Formation. Mechanisms of Memory, Chapter 11, Third Edition, Academic Press, invited, in press, expected publication date Jan 2023
  • H. Sontheimer and ML Olsen, Ionic Channels in Glia. Encyclopedia of Neuroscience, Oxford: Academic Press, Invited update, 2015
  • ML Olsen.  Potassium Channel Function in Astrocytes, Astrocytes: Methods and Protocols, Humana Press, Invited Review, ed. R. Milner, Springer Press, NY, 2012
  • ML Olsen and H. Sontheimer, Ionic Channels in Glia. Encyclopedia of Neuroscience, Oxford: Academic Press, volume 5, pp. 237-247. 2009 book cover art
  • H Sontheimer  and ML Olsen. Whole-Cell Patch Clamp Recordings, Patch-Clamp Analysis: Advanced Techniques, Second Edition, Humana Press, pp35-68, 2008
  • ML Olsen, H Sontheimer. Voltage-Gated Ion Channels in Glial Cells. Neuroglia, 2nd Edition, Oxford University Press, pp112-130, 2004